Short sleep duration in adults with congenital heart disease is associated with epicardial adipose tissue accumulation

Bibliographic Data

ID15524741
AuthorsBritta Stapel (0000-0003-1353-8064, Medizinische Hochschule Hannover, corresponding author), Lotta Winter (0000-0002-5197-1072, Medizinische Hochschule Hannover), Ivo Heitland (0000-0002-6672-7857, Medizinische Hochschule Hannover), Tim Halling (Medizinische Hochschule Hannover), Steffen Akkermann, Jochen Muke (Zentralklinik Bad Berka), Friederike Löffler (Medizinische Hochschule Hannover), Johann Bauersachs (0000-0002-9341-117X, Medizinische Hochschule Hannover), Mechthild Westhoff‐Bleck (Medizinische Hochschule Hannover), Mechthild Westhoff-Bleck, Kai G Kahl (0000-0002-8530-0605, Medizinische Hochschule Hannover)
Year2025
Volume16
Pages1490564-1490564
Publication date2025-09-17
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueFrontiers in Psychiatry (JOURNAL)
Journal identifiersISSN: 1664-0640 • E-ISSN: 1664-0640
PublisherFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2025.1490564
PMID41040943
OpenAlexW4414304993
LanguageEN
Citations received1
References cited61

Short sleep duration has been linked to an increased risk of cardiometabolic disorders and adverse outcomes, including hospitalization and mortality, in patients with cardiovascular disease (CVD). We assessed the association between sleep duration and cardiovascular parameters in adults with congenital heart disease (ACHD). Data were derived from the ongoing PSYConHEART study on morbidity and mortality factors in ACHD. Sleep duration, sociodemographic variables, and symptoms of anxiety and depression were measured using self-report questionnaires. Epicardial adipose tissue (EAT) was measured by echocardiography, and clinical parameters regarding the underlying heart condition, including serum levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), were assessed. Patients with a score N = 194). Short sleep duration (≤ 6 h/night) was present in 48 patients (25%). Two-way multivariate analysis with sleep duration (≤ 6 h/night vs. > 6 h/night) and age (≥ 35 vs. < 35 years) as independent variables, corrected for BMI, sex, and NYHA class, revealed a significant effect of sleep duration and age on prognostic CVD markers, namely EAT and NT-proBNP. Sleep duration was associated with CVD markers in older patients only. Sleep duration was associated with CVD markers only in older patients. In particular, EAT, which has prognostic value in cardiac diseases, was negatively impacted by short sleep duration. Sleep problems/disorders are amenable to psychological and pharmacological interventions. Therefore, assessment of sleep problems/disorders may be recommended as part of the multimodal treatment of ACHD patients

Anxiety · Brain natriuretic peptide · Depression (economics · Disease · Epicardial adipose tissue · Heart disease · Natriuretic peptide · Sleep (system call · Sleep disorder · Air Quality and Health Impacts · Cardiovascular Disease and Adiposity · Cardiovascular, Neuropeptides, and Oxidative Stress Research

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