Gut Microbiome
A Potential Indicator for Differential Diagnosis of Major Depressive Disorder and General Anxiety Disorder
Bibliographic Data
| ID | 15527478 |
|---|---|
| Authors | Zaiquan Dong (0000-0003-0226-239X, West China Hospital of Sichuan University), Xiaoling Shen (0000-0003-1688-7913, Sichuan University), Yanni Hao (0000-0002-2300-9951, West China Hospital of Sichuan University), Jin Li (0000-0001-9004-715X, Sichuan University), Haoran Li (0000-0002-2453-1995, West China Hospital of Sichuan University), Haizheng Xu (West China Hospital of Sichuan University), Yin Li (0000-0003-0838-5374, West China Hospital of Sichuan University), Li Yin (0000-0003-1951-1487), Weihong Kuang (0000-0002-3708-4987, West China Hospital of Sichuan University, corresponding author) |
| Year | 2021 |
| Volume | 12 |
| Pages | 651536-651536 |
| Publication date | 2021-09-13 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.651536 |
| PMID | 34589003 |
| OpenAlex | W3157812131 |
| Language | EN |
| References cited | 74 |
Background: Major depressive disorder (MDD) and general anxiety disorder (GAD) share many common features, leading to numerous challenges in their differential diagnosis. Given the importance of the microbiota-gut-brain axis, we investigated the differences in gut microbiota between representative cases of these two diseases and sought to develop a microbiome-based approach for their differential diagnosis. Methods: We enrolled 23 patients with MDD, 21 with GAD, and 10 healthy subjects (healthy crowd, HC) in the present study. We used 16S rRNA gene-sequencing analysis to determine the microbial compositions of the gut microbiome based on Illumina Miseq and according to the standard protocol. Results: GAD showed a significant difference in microbiota richness and diversity as compared with HC. Additionally, Otu24167, Otu19140, and Otu19751 were significantly decreased in MDD relative to HC, and Otu2581 and Otu10585 were significantly increased in GAD relative to MDD. At the genus level, the abundances of Sutterella and Fusicatenibacter were significantly lower in MDD relative to HC, and the abundances of Fusicatenibacter and Christensenellaceae _R7_group were significantly lower in GAD than in HC. The abundance of Sutterella was significantly higher whereas that of Faecalibacterium was significantly lower in GAD relative to MDD. Moreover, we observed that Christensenellaceae _R7_group negatively correlated with the factor score (Limited to Hopelessness) and total score of HAMD-24 ( p Fusicatenibacter negatively correlated with FT4 ( p Faecalibacterium , which negatively correlated with PTC ( p Conclusions: This study elucidated a unique gut-microbiome signature associated with MDD and GAD that could facilitate differential diagnosis and targeted therapy
Abundance (ecology · Amygdala · Anxiety · Bioinformatics · Biology · Generalized anxiety disorder · Gut flora · Hamd · Major depressive disorder · Microbiome · Psychiatry · Relative species abundance · Significant difference · Diet and metabolism studies · Gut microbiota and health · Medicine · Tryptophan and brain disorders · Ecology · Gastroenterology · Immunology · Internal Medicine
Depression and cortisol responses to psychological stress
Prevalence and Development of Psychiatric Disorders in Childhood and Adolescence
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Mind-altering microorganisms
The Structure of Common Mental Disorders
Gut Microbiota Changes in Patients With Major Depressive Disorder Treated With Vortioxetine
Systematic Review of Gut Microbiota and Major Depression
The Assessment of Anxiety States by Rating
| Citation velocity | historical |
|---|---|
| Highly cited | No |