Beyond the Fragile X protein
Neighborhood characteristics explain individual differences in IQ and adaptive behaviors of Fragile X syndrome
Bibliographic Data
| ID | 15527593 |
|---|---|
| Authors | Walker S McKinney (0000-0001-5281-3749, Cincinnati Children's Hospital Medical Center), Austin Corsmeier (Cincinnati Children's Hospital Medical Center), Ashley Dapore (Cincinnati Children's Hospital Medical Center), Christina Gross (0000-0001-6057-2527, Cincinnati Children's Hospital Medical Center), Kelli C Dominick (0000-0003-3775-2479, University of Cincinnati Medical Center), Craig A Erickson (0000-0003-4512-398X, University of Cincinnati Medical Center), Lauren Schmitt (0000-0002-2864-3767, Cincinnati Children's Hospital Medical Center, corresponding author), Lauren M Schmitt |
| Year | 2025 |
| Volume | 16 |
| Pages | 1636987-1636987 |
| Publication date | 2025-09-18 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Psychiatry (JOURNAL) |
| Journal identifiers | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Publisher | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2025.1636987 |
| PMID | 41048907 |
| OpenAlex | W4414306197 |
| Language | EN |
| References cited | 53 |
Our finding of stronger links between neighborhood resources and clinical outcomes in males with FXS is consistent with previous work and may reflect increased reliance on social-environmental supports in males who typically have more significant intellectual and adaptive deficits than females. Consistent associations between greater social resources, higher IQ, and stronger adaptive skills suggest social support (e.g., social cohesion, resource and knowledge sharing) may be a particularly salient target for intervention. Associations between economic resources and adaptive communication skills also highlight the benefits of targeted economic supports for families affected by FXS. Together, our findings underscore the role of social determinants of health as key contributors to individual differences and the importance of considering these factors in clinical studies of FXS
Adaptive behavior · Adaptive functioning · Fragile x · Fragile X syndrome · Resource (disambiguation · Salient · Autism Spectrum Disorder Research · Family and Disability Support Research · Genetics and Neurodevelopmental Disorders
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| Highly cited | No |
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