Determinants of growth in HIV ‐exposed and HIV ‐uninfected infants in the K abeho S tudy

Bibliographic Data

ID15535927
AuthorsCharlotte Lane (0000-0002-7730-6687, University of North Carolina at Chapel Hill, corresponding author), Emily A Bobrow (Nutrition Department The University of North Carolina at Chapel Hill Chapel Hill North Carolina USA), Emily Bobrow (University of North Carolina at Chapel Hill), Diuedonne Ndatimana (Elizabeth Glaser Pediatric AIDS Foundation Kigali Rwanda), Gilles Ndayisaba, Gilles F Ndayisaba (Elizabeth Glaser Pediatric AIDS Foundation Kigali Rwanda), Linda S Adair (0000-0002-3670-8073, University of North Carolina at Chapel Hill)
Year2019
Volume15
Issue3
Pagese12776-e12776
Publication date2019-01-04
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueMaternal and Child Nutrition (JOURNAL)
Journal identifiersISSN: 1740-8695 • E-ISSN: 1740-8709
PublisherWiley (PUBLISHER • GB)
DOI10.1111/mcn.12776
PMID30609287
OpenAlexW2908162778
LanguageEN
Citations received6
References cited39

HIV-exposed and HIV-uninfected (HEU) infants may be at increased risk of poor health and growth outcomes. We characterized infant growth trajectories in a cohort of HEU infants to identify factors associated with healthy growth. HIV-positive women participating in prevention of mother-to-child HIV transmission programmes in Kigali, Rwanda, were followed until their infants were 2 years old. Infant anthropometrics were regularly collected. Latent class analysis was used to categorize infant growth trajectories. Multiple logistic regression was used to estimate the odds of infants belonging to each growth trajectory class. On average, this population of HEU infants had moderate linear growth faltering, but only modest faltering in weight, resulting in mean weight-for-length z-score (WLZ) above the World Health Organization (WHO) median. Mean WLZ was 0.53, and mean length-for-age z-score (LAZ) was -1.14 over the first 2 years of life. We identified four unique WLZ trajectories and seven trajectories in LAZ. Low neonatal weight-for-age and a high rate of illness increased the likelihood that infants were in the lightest WLZ class. Shorter mothers were more likely to have infants with linear growth faltering. Female infants who were older at the end of exclusive breastfeeding were more likely to be in the second tallest LAZ class. In conclusion, the current WHO recommendations of Option B+ and extended breastfeeding may induce higher WLZ and lower LAZ early in infancy. However, there is considerable heterogeneity in growth patterns that is obscured by simply analysing average growth trends, necessitating the analysis of growth in subpopulations

Anthropometry · Breastfeeding · Environmental health · Logistic regression · Population · Child Nutrition and Feeding Issues · Child Nutrition and Water Access · Demography · Medicine · Poverty, Education, and Child Welfare · Internal Medicine · Pediatrics

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