Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4 months and 6 years after birth
Bibliographic Data
| ID | 15536135 |
|---|---|
| Authors | Michelle M Murphy (0000-0002-6304-6204, Universitat Rovira i Virgili, corresponding author), Joan Fernández‐Ballart (0000-0002-1320-6484, Instituto de Salud Carlos III), Joan D Fernandez‐Ballart (Area of Preventive Medicine and Public Health, Faculty of Medicine and Health Sciences Universitat Rovira i Virgili (URV), IISPV Reus Spain), Anne M Molloy (0000-0002-1688-9049, Trinity College Dublin), Josefa Canals (0000-0002-6209-9558, Universitat Rovira i Virgili) |
| Year | 2016 |
| Volume | 13 |
| Issue | 2 |
| Publication date | 2016-01-27 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Maternal and Child Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1740-8695 • E-ISSN: 1740-8709 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1111/mcn.12289 |
| PMID | 26817572 |
| OpenAlex | W2333718794 |
| Language | EN |
| Citations received | 2 |
| References cited | 36 |
Prenatal methyl donor deficiency leads to homocysteine accumulation in the brain and impaired neurodevelopment in rats. We investigated the effect of moderately elevated preconception fasting total plasma homocysteine (tHcy) on child neurodevelopment in a prospective study of 67 and 76 mother–child pairs at 4 months and 6 years of age, respectively. Fasting blood samples at 2–10 weeks preconception, from the cord (nonfasting) and the mother and child 6 years after birth, were collected. Psychomotor and mental development were assessed at 4 months using the Bayley Scale of Infant Development (BSID) and cognitive development at 6 years using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Highest tertile preconception tHcy (≥9.04 μmol/L) was categorized as moderately elevated and low‐mid tertile tHcy as normal. Children, born to mothers with moderately elevated compared to normal preconception tHcy, scored lower [mean (95% CI)] in the BSID psychomotor [115 (105, 124) vs. 126 (121, 130), p = 0.03] and mental [101 (93, 109) vs. 113 (107, 119), p = 0.03] development tests. Multiple logistic regression analysis showed that moderately elevated compared to normal preconception tHcy was associated with greater probability, OR (95%CI), of scoring in the lowest tertile for BSID psychomotor development (≤120): 4.0 (1.1, 14.3) and lowest tertiles for WPPSI full (≤111), verbal (≤104) and performance (≤111), intellectual quotient: 6.0 (1.5, 23.7), 3.5 (1.1, 11.2) and 4.1 (1.1, 15.7), respectively. We conclude that moderately elevated preconception tHcy is inversely associated with psychomotor and cognitive development scores in infants and children
Bayley Scales of Infant Development · Cognition · Cord blood · Homocysteine · Intelligence quotient · Obstetrics · Psychiatry · Psychomotor learning · Wechsler Adult Intelligence Scale · Wechsler Intelligence Scale for Children · Wechsler Preschool and Primary Scale of Intelligence · Birth, Development, and Health · Breastfeeding Practices and Influences · Folate and B Vitamins Research · Medicine · Internal Medicine · Pediatrics
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Moderately elevated maternal homocysteine at preconception is inversely associated with cognitive performance in children 4 months and 6 years after birth
| Citations per year | 0.2 |
|---|---|
| Citation span | 2016 - 2019 (4) |
| Highly cited | No |