Maternal aflatoxin exposure during pregnancy and adverse birth outcomes in Uganda
Bibliographic Data
| ID | 15537262 |
|---|---|
| Authors | Jacqueline M Lauer (0000-0001-8434-6583, Tufts University, corresponding author), Christopher Duggan (0000-0001-8083-8193, Tufts University), Christopher P Duggan (USAID Feed the Future Innovation Lab for Nutrition Tufts University Boston Massachusetts), Lynne M Ausman (0000-0001-8145-9590, Tufts University), Jeffrey K Griffiths (Tufts University), Patrick Webb (0000-0002-9857-3354, Tufts University), Jia‐Sheng Wang (University of Georgia), Kathy S Xue (0000-0001-7944-8999, University of Georgia), Edgar Agaba (0000-0003-4177-6086, Tufts University), Nathan Nshakira (Uganda Christian University), Shibani Ghosh (0000-0001-5893-6774, Tufts University) |
| Year | 2018 |
| Volume | 15 |
| Issue | 2 |
| Pages | e12701-e12701 |
| Publication date | 2018-09-22 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Maternal and Child Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1740-8695 • E-ISSN: 1740-8709 |
| Publisher | Wiley (PUBLISHER • GB) |
| DOI | 10.1111/mcn.12701 |
| PMID | 30242967 |
| OpenAlex | W2892942664 |
| Language | EN |
| Citations received | 5 |
| References cited | 36 |
Aflatoxins are toxic metabolites of Aspergillus moulds and are widespread in the food supply, particularly in low- and middle-income countries. Both in utero and infant exposure to aflatoxin B 1 (AFB 1 ) have been linked to poor child growth and development. The objective of this prospective cohort study was to investigate the association between maternal aflatoxin exposure during pregnancy and adverse birth outcomes, primarily lower birth weight, in a sample of 220 mother-infant pairs in Mukono district, Uganda. Maternal aflatoxin exposure was assessed by measuring the serum concentration of AFB 1 -lysine (AFB-Lys) adduct at 17.8 ± 3.5 (mean ± SD)-week gestation using high-performance liquid chromatography. Anthropometry and birth outcome characteristics were obtained within 48 hr of delivery. Associations between maternal aflatoxin exposure and birth outcomes were assessed using multivariable linear regression models adjusted for confounding factors. Median maternal AFB-Lys level was 5.83 pg/mg albumin (range: 0.71-95.60 pg/mg albumin, interquartile range: 3.53-9.62 pg/mg albumin). In adjusted linear regression models, elevations in maternal AFB-Lys levels were significantly associated with lower weight (adj-β: 0.07; 95% CI: -0.13, -0.003; p = 0.040), lower weight-for-age z-score (adj-β: -0.16; 95% CI: -0.30, -0.01; p = 0.037), smaller head circumference (adj-β: -0.26; 95% CI: -0.49, -0.02; p = 0.035), and lower head circumference-for-age z-score (adj-β: -0.23; 95% CI: -0.43, -0.03; p = 0.023) in infants at birth. Overall, our data suggest an association between maternal aflatoxin exposure during pregnancy and adverse birth outcomes, particularly lower birth weight and smaller head circumference, but further research is warranted
Aflatoxin · Anthropometry · Biology · Birth weight · Confounding · Interquartile range · Obstetrics · Pregnancy · Prospective cohort study · Carcinogens and Genotoxicity Assessment · Medicine · Mycotoxins in Agriculture and Food · Wheat and Barley Genetics and Pathology · Biotechnology · Internal Medicine · Physiology
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Maternal aflatoxin exposure during pregnancy and adverse birth outcomes in Uganda
| Unique citing works | 5 |
|---|---|
| Citations per year | 0,63 |
| Citation span | 2018 - 2025 (8) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 5 |