Combined atmospheric oxidant capacity and increased levels of exhaled nitric oxide
Bibliographic Data
| ID | 15549876 |
|---|---|
| Authors | Changyuan Yang (0000-0001-7153-9159, Fudan University), Huichu Li (0000-0002-6142-0282, Fudan University), Renjie Chen (0000-0002-9448-0820, Fudan University, corresponding author), Wenxi Xu (0009-0007-6282-6632), Cuicui Wang (0000-0002-0540-873X, Fudan University), Lap Ah Tse (0000-0003-0355-6218, Chinese University of Hong Kong), Zhuohui Zhao (0000-0001-8596-0278, Fudan University), Haidong Kan (0000-0002-1871-8999, Fudan University, corresponding author) |
| Year | 2016 |
| Volume | 11 |
| Issue | 7 |
| Pages | 074014-074014 |
| Publication date | 2016-07-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Environmental Research Letters (JOURNAL) |
| Journal identifiers | ISSN: 1748-9326 • E-ISSN: 1748-9326 |
| Publisher | IOP Publishing (PUBLISHER • GB) |
| DOI | 10.1088/1748-9326/11/7/074014 |
| OpenAlex | W2468402659 |
| Language | EN |
| Citations received | 1 |
| References cited | 26 |
Nitrogen dioxide and ozone are two interrelated oxidative pollutants in the atmosphere. Few studies have evaluated the health effects of combined oxidant capacity (O _x ). We investigated the short-term effects of O _x on fractional exhaled nitric oxide (FeNO), a well-established biomarker for airway inflammation, in a group of chronic obstructive pulmonary disease patients. Real-time concentrations of O _x were obtained by calculating directly the sum of nitrogen dioxide and ozone. Linear mixed-effect models were applied to explore the acute effects of O _x on FeNO levels. Short-term exposure to O _x was significantly associated with elevated FeNO. This effect was strongest in the first 24 h after exposure, and was robust to the adjustment of PM _2.5 . A 10 μ g m ^−3 increase in 24 h average concentrations of O _x was associated with 4.28% (95% confidence interval: 1.19%, 7.37%) increase in FeNO. The effect estimates were statistically significant only among males, elders, and those with body mass index ≥24 kg m ^−2 , a comorbidity, higher educational attainment, or moderate airflow limitation. This analysis demonstrated an independent effect of O _x on respiratory inflammation, and suggested that a single metric O _x might serve as a preferable indicator of atmospheric oxidative capacity in further air pollution epidemiological studies
Asthma · Body mass index · Confidence interval · Exhaled nitric oxide · Inflammation · Nitric oxide · Nitrogen dioxide · Ozone · Pollutant · Systemic inflammation · Air Quality and Health Impacts · Air Quality Monitoring and Forecasting · Chemistry · Climate Change and Health Impacts · Medicine · Environmental Chemistry · Gastroenterology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,25 |
| Citation span | 2022 - 2022 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |