Predictors of Early Language Outcomes in Children with Connexin 26 Hearing Loss across Three Countries

Bibliographic Data

ID15712451
AuthorsDaniel Holzinger (0000-0001-6634-6117, Johannes Kepler University of Linz), Magdalena Dall (Johannes Kepler University of Linz, corresponding author), Sandra Kiblböck (Johannes Kepler University of Linz), Emile Dirks (0000-0003-4391-4462, Utrecht University), Peter Carew (0000-0003-4133-5723, The University of Melbourne), Libby Smith (Murdoch Children’s Research Institute, Parkville, Melbourne, VIC 3052, Australia), Libby J Smith (0009-0004-1241-8970, Murdoch Children's Research Institute), Lilian Downie (0000-0003-3914-5592, The University of Melbourne), Daisy A Shepherd (0000-0001-8540-0473, The University of Melbourne), Valerie Sung (0000-0003-2029-6331, Royal Children's Hospital)
Year2022
Volume9
Issue7
Pages990-990
Publication date2022-07-01
Open AccessYes
TypeARTICLE
VenueChildren (JOURNAL)
Journal identifiersISSN: 2227-9067 • E-ISSN: 2227-9067
PublisherMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/children9070990
PMID35883974
OpenAlexW4283769280
LanguageEN
References cited51

GJB2-associated hearing loss (GJB2-HL) is the most common genetic cause of hearing loss in children. However, little is known about the clinical characteristics and early language outcomes in population-oriented samples including children with different degrees of hearing loss. Insight into these characteristics are relevant for the counselling of parents. Our sample consisted of 66 children at approximately 2 years of age (17-32 months) with bilateral hearing loss due to GJB2 from three population-based cohorts in Austria, Australia and the Netherlands. Predictors of early vocabulary, including demographic, audiological, genetic and intervention variables and the role of medical comorbidities and nonverbal cognition were examined. The vocabulary scores of children with GJB2-HL were approximately 0.7 standard deviations (SDs) below the norms of children with typical hearing. Age at access to family-centered early intervention and first-born position among siblings predicted language outcomes, whereas the degree of hearing loss and genetic subtype were not significantly correlated with expressive vocabulary. In children with GJB2-HL, early access to family-centered early intervention significantly affected language outcomes at the age of two

Audiology · Developmental psychology · Hearing loss · Intervention (counseling · Linguistics · Nonverbal communication · Population · Psychiatry · Vocabulary · Hearing Impairment and Communication · Hearing Loss and Rehabilitation · Hearing, Cochlea, Tinnitus, Genetics · Medicine · Psychology · Pediatrics

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