Argonaute2 and Argonaute4 Involved in the Pathogenesis of Kawasaki Disease via mRNA Expression Profiles

The data revealed that the AGO2 and AGO4 genes displayed significant within-group differences with p = 0.034 and 0.007, respectively. In AGO2, significant differences were observed between KD1 vs. HC + FC with p = 0.034. KD1 appears higher than the other specimens in AGO4, with significant differences between KD1 and HC ( p = 0.033), KD1 and FC ( p = 0.033), KD1 and KD3 ( p = 0.013), and KD1 and HC + FC ( p = 0.007). We observed no substantial differences in AGO1 or AGO3 ( p > 0.05). There were no significant differences between AGO(s) and coronary artery lesions or intravenous immunoglobulin resistance. ( p > 0.05) Conclusion: Endothelial cell inflammation and injury, two basic pathological mechanisms, are thought to be involved in coronary endothelial dysfunction in KD. AGO2 and AGO4 are likely to participate in the endothelial dysfunction of children with KD, with AGO4 potentially playing a key role, while AGO1 and AGO3 appear not to participate

Biology · Disease · Expression (computer science · Gene · Kawasaki disease · Messenger RNA · Pathogenesis · Pathology · Cardiac Structural Anomalies and Repair · Computer Science · Coronary Artery Anomalies · Kawasaki Disease and Coronary Complications · Medicine · Cell Biology · Genetics · Immunology · Internal Medicine