Basophils Predict Mite Sensitization in Patients with Kawasaki Disease
Bibliographic Data
| ID | 15715877 |
|---|---|
| Authors | Ling‐Sai Chang (0000-0002-3591-1563, Chang Gung University), Ling-Sai Chang (Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan), Ying‐Hsien Huang (0000-0002-7127-0046, Chang Gung University), Hsin-Yu Chang (0000-0001-5577-2356, Chang Gung University), Zon‐Min Lee (0000-0003-3470-2468, Tajen University), Zon-Min Lee (Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan), Wei-Ling Feng (Kaohsiung Chang Gung Memorial Hospital), Ho‐Chang Kuo (0000-0002-3295-2984, Chang Gung University, corresponding author) |
| Year | 2023 |
| Volume | 10 |
| Issue | 7 |
| Pages | 1209-1209 |
| Publication date | 2023-07-12 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Children (JOURNAL) |
| Journal identifiers | ISSN: 2227-9067 • E-ISSN: 2227-9067 |
| Publisher | Multidisciplinary Digital Publishing Institute (PUBLISHER • CH) |
| DOI | 10.3390/children10071209 |
| PMID | 37508706 |
| OpenAlex | W4384201441 |
| Language | EN |
| References cited | 39 |
Background : Patients with Kawasaki disease (KD) are at a significantly increased risk of allergic diseases. Immunoglobulin E (IgE) is an immunoglobulin that mediates allergic sensitization to various allergens and is related to various allergic diseases. However, few studies have analyzed specific IgE on allergy biomarkers after KD is diagnosed. Objective : This study aimed to investigate the pattern of specific IgE levels against food and inhalant allergens. Methods : This retrospective study was conducted in Taiwan to identify patients admitted with KD. A subset of 453 admitted KD children younger than or equal to five years of age with intravenous immunoglobulin (IVIG) was followed up at our clinic with available specific IgE data. Results : The most common allergens were Dermatophagoides farina or pteronyssinus, house-dust, and cockroach mix. Positive specific IgE for Dermatophagoides farina or pteronyssinus was less common in children diagnosed with KD who were two years old or younger ( p = 0.028). KD patients with higher basophils before IVIG ( p = 0.010 and 0.018 for two different mites) and higher C-reactive protein (CRP, p = 0.030 and 0.028) after IVIG were at higher risk of mite sensitization. Integrated mite sensitization demonstrated higher basophils before IVIG, age at KD diagnosis, and the male sex to be clinically meaningful after logistic regression models. Conclusions : This study is the first to suggest that specific IgE in KD patients may be correlated with age at KD diagnosis, as well as basophils. Further longitudinal prospective studies are warranted to clarify the unique profile of specific IgE in KD patients
Allergen · Allergy · Antibody · Biology · Cockroach · House dust mite · Immunoglobulin E · Mite · Sensitization · Autoimmune and Inflammatory Disorders Research · Kawasaki Disease and Coronary Complications · Medicine · Respiratory viral infections research · Immunology
| Highly cited | No |
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