Effects of Overtraining Upon Drug-State Dependency in Discrimination Learning in White Rats

Groups ND10ND, NDND and NNDN were treated daily with saline (N), and Group DDND was treated with 20 mg/kg of chlordiazepoxide (D) 10 days prior to black-white escape discrimination training. Training 1 consisted of 20 trials per day on a discrimination task until a 90% correct criterion was met for all groups and Group ND10ND was given 10 additional training days; Groups ND10ND, NDND and DDND were injected i.p. with D, 30 min prior to each daily session and Group NNDN with N. Following Training 1, all groups were shifted in states and trained on the same task to the same criterion (Training 2), after which the state was shifted back to that in Training 1 and run only a day (Training 3). As in previous studies, discrimination learning was slightly depressed by D in Training 1, but otherwise there were no differences among the groups. With the state shift, errors increased for all groups but the overtrained group (ND10ND) made fewer errors and attained criterion faster than the other 2 groups (NDND and DDND) in the same state (Training 2). When the state was shifted again, Group ND10ND performed best among the 4 groups and they made fewer errors than on the preceding day in the opposite state (Training 3). Thus overtraining produced more transfer to a different state (D to N in this study) and better retrieval with the restored state (D)

Audiology · Chlordiazepoxide · Developmental psychology · Diazepam · Discrimination learning · Overtraining · Physical therapy · Psychiatry · Saline · Training (meteorology) · Analytical Chemistry and Chromatography · Analytical Methods in Pharmaceuticals · Computational Drug Discovery Methods · Internal Medicine · Medicine · Psychology

• Drug-State Dependency as a Function of Overtraining in Rats

  Shinkuro Iwahara, SETSUKO NOGUCHI•Japanese Psychological Research•1972

  Add to list

• Effect of Chlordiazepoxide Upon Experimental Extinction in the Straight Runway as a Function of Partial Reinforcement in the Rat

  Shinkuro Iwahara, Neiichi Nagamura et al.•Japanese Psychological Research•1967

  Add to list

• Effect of Chlordiazepoxide Upon Food Intake and Spontaneous Motor Activity of the Rat as a Function of Hours of Food Deprivation

  Shinkuro Iwahara, Tsuneo Iwasaki•Japanese Psychological Research•1969

  Add to list

• Journal of Comparative and Physiological Psychology

  W K Estes•American Psychologist•1965

  Add to list