History of Sudden Unexpected Loss Is Associated With Elevated Interleukin-6 and Decreased Insulin-Like Growth Factor-1 in Women in an Urban Primary Care Setting
Bibliographic Data
| ID | 19306830 |
|---|---|
| Authors | Banu Çankaya (0000-0003-1882-0528), Benjamin P Chapman (0000-0002-5170-3131, University of Rochester, corresponding author), Nancy L Talbot, Jan A Moynihan (0000-0001-9513-5028), Jan Moynihan, Paul R Duberstein (0000-0001-6882-0898) |
| Year | 2009 |
| Volume | 71 |
| Issue | 9 |
| Pages | 914-919 |
| Publication date | 2009-11-01 |
| Open Access | No |
| Type | ARTICLE |
| Venue | Psychosomatic Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0033-3174 • E-ISSN: 1534-7796 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/psy.0b013e3181be7aa8 |
| PMID | 19875631 |
| PMCID | PMC2886971 |
| OpenAlex | W2018251352 |
| Language | EN |
| Citations received | 6 |
| References cited | 48 |
OBJECTIVE: To investigate the hypothesis that a history of sudden unexpected loss including number of losses and type of loss (death due to unnatural versus natural causes) would be associated with the magnitude of dysregulation. The sudden unexpected death of a loved one confers risk of morbidity and mortality, perhaps due to dysregulation in the immune/inflammatory and endocrine systems. METHODS: Female primary care patients aged >or=40 years (n = 75) completed questionnaires, a clinical interview, and a blood draw. Interleukin (IL)-6 and insulin-like growth factor (IGF)-1 were assayed, using standard enzyme-linked immunosorbent assay protocols and anticytokine antibody pairs. RESULTS: History of sudden loss was positively associated with IL-6 (mean = 4.07 pg/mL; log(10) values, B = 0.314, p = .009) and negatively associated with IGF-1 (mean = 97.05 ng/mL; B = -0.277, p = .023). A linear relationship parsimoniously captured the association between ordered categories of lifetime loss (0, 1, 2-5, 5+) and increases in log(10) IL-6 (B = 0.107, p = .005) and decreases in IGF-1 (B = -0.116, p = .005). Adjusting for illness burden, depressive symptom severity, and obesity did not change the observed associations. The hypothesized effect of type of loss was not supported. CONCLUSIONS: These preliminary findings encourage further investigations to elucidate pathways from sudden unexpected loss to biomarker changes that increase risk for morbidity and mortality
Biology · Biomarker · Growth factor · Immune system · Insulin-like growth factor · Obesity · Receptor · Risk factor · Sudden death · Weight loss · Cancer survivorship and care · Endocrinology · Fibromyalgia and Chronic Fatigue Syndrome Research · Immunology · Internal Medicine · Medicine · Psychosomatic Disorders and Their Treatments
Social Epidemiology
Psychiatric Disorders Among Bereaved Persons
Hostile Marital Interactions, Proinflammatory Cytokine Production, and Wound Healing
Physiology and Neurobiology of Stress and Adaptation
Treatment of complicated grief
Mortality in parents after death of a child in Denmark
Psychoneuroimmunology
Chronic stress and age-related increases in the proinflammatory cytokine IL-6
Treatment of Complicated Grief
Elevated C-Reactive Protein Levels in Overweight and Obese Adults
Trauma and Posttraumatic Stress Disorder in the Community
Prevalence of Multimorbidity Among Adults Seen in Family Practice
The Impact of Suicide on the Family
The influence of symptoms of prolonged grief disorder, depression, and anxiety on quality of life among bereaved adults
Is Suicide Bereavement Different? A Reassessment of the Literature
Social Environment Effects on Health and Aging
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Development and preliminary validation of a brief broad-spectrum measure of trauma exposure
Research Agenda for Frailty in Older Adults
Sex Differences in Health Effects of Family Death or Illness
Psychoneuroimmunology and Psychosomatic Medicine
Posttraumatic Stress Symptoms, Intrusive Thoughts, Loss, and Immune Function after Hurricane Andrew
The Influence of Stress Intrusion on Immunodepression in Generalized Anxiety Disorder Patients and Controls
Impact of Social Environment Characteristics on Neuroendocrine Regulation
Does Subjective Social Status Predict Health and Change in Health Status Better Than Objective Status
Psychological Adjustment to Sudden and Anticipated Spousal Loss Among Older Widowed Persons
Does Grief Counseling Work
Effect of conjugal bereavement on mortality of the bereaved spouse in participants of the Renfrew/Paisley Study
Mortality after the death of a spouse
Optimal Indicators of Socioeconomic Status for Health Research
Psychological Stress and the Human Immune System
| Citations per year | 0.46 |
|---|---|
| Citation span | 2013 - 2019 (7) |
| Highly cited | No |