Two or more significant life-events in 6-months are associated with lower rates of HIV treatment and virologic suppression among youth with HIV in Uganda and Kenya

Bibliographic Data

ID19439715
AuthorsFlorence Mwangwa (0000-0001-9467-0950, Infectious Diseases Research Collaboration, Kampala, Uganda), Edwin D Charlebois (0000-0001-7237-2119, Departments of Medicine and Pediatrics, University of California, San Francisco, CA, USA), James Ayieko (0000-0002-0324-4006, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya), Winter Olio (Kenya Medical Research Institute (KEMRI), Nairobi, Kenya), Douglas Black (Departments of Medicine and Pediatrics, University of California, San Francisco, CA, USA), James Peng (0000-0002-8245-8319, Departments of Medicine and Pediatrics, University of California, San Francisco, CA, USA), Dalsone Kwarisiima (0000-0003-2886-9261, Infectious Diseases Research Collaboration, Kampala, Uganda), Jane Kabami (0000-0002-0265-3174, Infectious Diseases Research Collaboration, Kampala, Uganda), Laura B Balzer (0000-0002-3730-410X, Department of Biostatistics & Epidemiology, University of Massachusetts, Amherst, MA, USA), Maya L Petersen (0000-0002-5505-153X, Berkeley School of Public Health, University of California, Berkeley, CA, USA), Bill G Kapogiannis (0000-0003-0754-9090, Maternal and Pediatric Infectious Diseases Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development at the National Institutes of Health, Bethesda, MD, USA), Moses R Kamya (0000-0001-9106-4234, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda), Diane V Havlir (0000-0003-0761-3136, Departments of Medicine and Pediatrics, University of California, San Francisco, CA, USA), Theodore Ruel (0000-0002-1105-9126, Departments of Medicine and Pediatrics, University of California, San Francisco, CA, USA, corresponding author)
Year2023
Volume35
Issue1
Pages95-105
Publication date2023-01-02
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueAIDS Care (JOURNAL)
Journal identifiersISSN: 0954-0121 • E-ISSN: 1360-0451
PublisherInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2022.2052260
PMID35578398
OpenAlexW4280502275
LanguageEN
Citations received3
References cited44

Youth living with HIV in sub-Saharan Africa have poor HIV care outcomes. We determined the association of recent significant life-events with HIV antiretroviral treatment (ART) initiation and HIV viral suppression in youth aged 15–24 years living with HIV in rural Kenya and Uganda. This was a cross-sectional analysis of 995 youth enrolled in the SEARCH Youth study. At baseline, providers assessed recent (within 6 months) life-events, defined as changes in schooling/employment, residence, partnerships, sickness, incarceration status, family strife or death, and birth/pregnancy, self-reported alcohol use, being a parent, and HIV-status disclosure. We examined the frequencies of events and their association with ART status and HIV viral suppression ( 2 significant life-events (aOR = 0.61, 95% CI:0.45-0.85) and consuming alcohol (aOR = 0.61, 95% CI:0.43-0.87) were associated with a lower odds of HIV viral suppression, while disclosure of HIV-status to partner (aOR = 2.39, 95% CI:1.6-3.5) or to family (aOR = 1.86, 95% CI:1.3-2.7), being a parent (aOR = 1.8, 95% CI:1.2-2.5), and being single (aOR = 1.6, 95% CI:1.3-2.1) had a higher odds. This suggest that two or more recent life-events and alcohol use are key barriers to ART initiation and achievement of viral suppression among youth living with HIV in rural East Africa.Trial registration: ClinicalTrials.gov identifier: NCT03848728

Biology · Cross-sectional study · Logistic regression · Odds · Odds ratio · Pregnancy · Residence · Viral load · Young adult · Adolescent Sexual and Reproductive Health · Demography · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Gerontology · Immunology · Internal Medicine

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