Topical emollient therapy in the management of severe acute malnutrition in children under two
A randomized controlled clinical trial in Bangladesh
Bibliographic Data
| ID | 19551599 |
|---|---|
| Authors | K M Shahunja (0000-0002-9345-206X, International Centre for Diarrhoeal Disease Research), KM Shahunja, Tahmeed Ahmed (0000-0002-4607-7439, International Centre for Diarrhoeal Disease Research), Md Iqbal Hossain (0000-0002-6827-4505, International Centre for Diarrhoeal Disease Research), Mustafa Mahfuz (0000-0002-4090-785X, International Centre for Diarrhoeal Disease Research), Lindsay Kendall (0000-0003-2812-0154, GlaxoSmithKline (United Kingdom)), Xinyi Zhu (0009-0007-3591-5955, GlaxoSmithKline (United Kingdom)), Krishan Singh (0000-0002-0091-0907, GlaxoSmithKline (United Kingdom)), Jonathan M Crowther (0000-0002-2549-396X), Sunita Singh (0000-0001-5519-1252, GlaxoSmithKline (United Kingdom)), Rachel A Gibson (0000-0002-1338-1290, GlaxoSmithKline (United Kingdom)), Gary L Darmstadt (0000-0002-7522-5824, Stanford University, corresponding author) |
| Year | 2020 |
| Volume | 10 |
| Issue | 1 |
| Pages | 010414-010414 |
| Publication date | 2020-06-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Global Health (JOURNAL) |
| Journal identifiers | ISSN: 2047-2978 • E-ISSN: 2047-2986 |
| Publisher | International Society of Global Health (PUBLISHER • GB) |
| DOI | 10.7189/jogh.10.010414 |
| PMID | 32509290 |
| OpenAlex | W3026273963 |
| Language | EN |
| Citations received | 3 |
| References cited | 29 |
BACKGROUND: Topical emollient therapy can improve neonatal health and growth and potentially provides an additional avenue for augmenting the provision of nutrition to children with severe acute malnutrition (SAM). We hypothesised that topical treatment of hospitalised children with SAM using sunflower seed oil (SSO), in addition to standard-of-care for SAM, would improve skin barrier function and weight gain, reduce risk of infection, and accelerate clinical recovery. METHODS: We conducted a randomised, two-arm, controlled, unblinded clinical trial in 212 subjects aged 2 to 24 months who were admitted for care of SAM at the 'Dhaka Hospital' of icddr,b during January 2016 to November 2017. Enrollment was age-stratified into 2 to <6 months and 6 to 24 months age groups in a 1:2 ratio. All children received SAM standard-of-care, and the SSO group was also treated with 3 g of SSO per kg body weight three times daily for 10 days. Primary outcome was rate of weight gain over the 10-day study period. Secondary endpoints included rate of nosocomial infection, time to recovery from acute illness, skin condition score, rate of transepidermal water loss (TEWL) and C-reactive protein (CRP) level. RESULTS: = 0.019) in the younger age stratum. CONCLUSIONS: Topical therapy with SSO was beneficial for children with SAM when applied as adjunctive therapy. A community-based trial with a longer intervention period is recommended to validate these results. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02616289
Body weight · Clinical endpoint · Clinical trial · Confidence interval · Malnutrition · Odds ratio · Randomized controlled trial · Rate ratio · Severe Acute Malnutrition · Weight gain · Child Nutrition and Feeding Issues · Dermatology and Skin Diseases · Medicine · Neonatal skin health care · Internal Medicine · Pediatrics
Status and utilization of child health and nutritional services among low-income urban households in Bangladesh
Optimised emollient mixture for skin barrier repair
Topical emollient therapy with sunflower seed oil alters the skin microbiota of young children with severe acute malnutrition in Bangladesh
| Unique citing works | 3 |
|---|---|
| Citations per year | 0.6 |
| Citation span | 2021 - 2022 (2) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 3 |