Topical emollient therapy with sunflower seed oil alters the skin microbiota of young children with severe acute malnutrition in Bangladesh
A randomised, controlled study
Bibliographic Data
| ID | 19552013 |
|---|---|
| Authors | Natalie Fischer (0009-0002-2991-612X, Stanford University), Gary L Darmstadt (0000-0002-7522-5824, Stanford University), K M Shahunja (0000-0002-9345-206X, International Centre for Diarrhoeal Disease Research), KM Shahunja, Jonathan M Crowther (0000-0002-2549-396X, JMC Scientific Consulting Ltd, Egham, Surrey, UK), Lindsay Kendall (0000-0003-2812-0154, GlaxoSmithKline (United Kingdom)), Rachel A Gibson (0000-0002-1338-1290, GlaxoSmithKline (United Kingdom)), Tahmeed Ahmed (0000-0002-4607-7439, Food and Nutrition Service), David A Relman (0000-0001-8331-1354, Stanford University, corresponding author) |
| Year | 2021 |
| Volume | 11 |
| Pages | 04047-04047 |
| Publication date | 2021-07-17 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Global Health (JOURNAL) |
| Journal identifiers | ISSN: 2047-2978 • E-ISSN: 2047-2986 |
| Publisher | International Society of Global Health (PUBLISHER • GB) |
| DOI | 10.7189/jogh.11.04047 |
| PMID | 34386216 |
| OpenAlex | W3191509369 |
| Language | EN |
| Citations received | 1 |
| References cited | 44 |
BACKGROUND: Topical emollient therapy with sunflower seed oil (SSO) reduces risk of sepsis and mortality in very preterm infants in low- or middle-income countries (LMICs). Proposed mechanisms include modulation of skin and possibly gut barrier function. The skin and gut microbiota play important roles in regulating barrier function, but the effects of emollient therapy on these microbiotas are poorly understood. METHODS: We characterised microbiota structure and diversity with 16S rRNA gene amplicon sequence data and ecological statistics in 20 children with severe acute malnutrition (SAM) aged 2-24 months, at four skin sites and in stool, during a randomised, controlled trial of emollient therapy with SSO in Bangladesh. Microbes associated with therapy were identified with tree-based sparse discriminant analysis. RESULTS: = 0.060). CONCLUSIONS: Emollient therapy altered the skin microbiota in a consistent and temporally coherent manner. We speculate that therapy with SSO enhances skin barrier function in part through alterations in the microbiota, and through systemic mechanisms. Strategies to strengthen skin and gut barrier function in populations at risk, such as children in LMICs like Bangladesh, might include deliberate manipulation of their skin microbiota. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02616289
Bioinformatics · Biology · Gut flora · Microbiome · Randomized controlled trial · Advancements in Transdermal Drug Delivery · Dermatology and Skin Diseases · Medicine · Neonatal skin health care · Dermatology · Immunology · Internal Medicine
| Unique citing works | 1 |
|---|---|
| Citations per year | 0.25 |
| Citation span | 2022 - 2022 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |