Mapping associations of polygenic scores with autistic and ADHD traits in a single city region

Bibliographic Data

ID21344858
AuthorsZoe E Reed (0000-0002-2990-6979, MRC Integrative Epidemiology Unit University of Bristol Bristol UK, corresponding author), Richard Thomas (0000-0002-3325-1952, Department of Population Health Sciences Bristol Medical School University of Bristol Bristol UK), Andy Boyd (0000-0002-8614-3728, Department of Population Health Sciences Bristol Medical School University of Bristol Bristol UK), Gareth J Griffith (0000-0003-0481-3175, MRC Integrative Epidemiology Unit University of Bristol Bristol UK), Tim T Morris (0000-0001-8178-6815, Centre for Longitudinal Studies Social Research Institute University College London London UK), Dheeraj Rai (0000-0002-7239-3523, Department of Population Health Sciences Bristol Medical School University of Bristol Bristol UK), David Manley (0000-0003-1864-5141, School of Geographical Sciences University of Bristol Bristol UK), Gregory D Smith (0000-0002-1407-8314, University of Bristol), George Davey Smith (MRC Integrative Epidemiology Unit University of Bristol Bristol UK), Oliver S P Davis (0000-0002-6448-3684, MRC Integrative Epidemiology Unit University of Bristol Bristol UK)
Year2025
Volume66
Issue2
Pages202-213
Publication date2025-02-01
Open AccessYes
TypeARTICLE
VenueJournal of Child Psychology and Psychiatry (JOURNAL)
Journal identifiersISSN: 0021-9630 • E-ISSN: 1469-7610
PublisherWiley (PUBLISHER • GB)
DOI10.1111/jcpp.14047
PMID39143033
OpenAlexW4401624981
LanguageEN
References cited52

BACKGROUND: The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants? METHODS: We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N = 4,255-6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD. RESULTS: Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences. CONCLUSIONS: These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits

Association (psychology) · Autism · Autism spectrum disorder · Autistic traits · Biology · Developmental psychology · Gene–environment interaction · Genotype · Polygenic risk score · Single-nucleotide polymorphism · Attention Deficit Hyperactivity Disorder · Autism Spectrum Disorder Research · Clinical Psychology · Genetics · Health, Environment, Cognitive Aging · Psychology

Tools

Open DOIOpen Access