Delivery strategies for malaria vaccination in areas with seasonal malaria transmission
Bibliographic Data
Background Seasonal vaccination with the RTS,S/AS01 E malaria vaccine given alongside seasonal malaria chemoprevention (SMC) substantially reduces malaria in young children. The WHO has recommended the use of RTS,S/AS01 E , including seasonal vaccination, in areas with seasonal malaria transmission. This study aimed to identify potential strategies to deliver RTS,S/AS01 E , and assess the considerations and recommendations for delivery of seasonal malaria vaccination in Mali, a country with highly seasonal malaria. Methods Potential delivery strategies for RTS,S/AS01 E in areas with seasonal malaria were identified through a series of high level discussions with the RTS,S/AS01 E plus SMC trial investigators, international and national immunisation and malaria experts, and through the development of a theory of change. These were explored through qualitative in-depth interviews with 108 participants, including national-level, regional-level and district-level malaria and immunisation programme managers, health workers, caregivers of children under 5 years of age, and community stakeholders. A national-level workshop was held to confirm the qualitative findings and work towards consensus on an appropriate strategy. Results Four delivery strategies were identified: age-based vaccination delivered via the Essential Programme on Immunisation (EPI); seasonal vaccination via EPI mass vaccination campaigns (MVCs); a combination of age-based priming vaccination doses delivered via the EPI clinics and seasonal booster doses delivered via MVCs; and a combination of age-based priming vaccination doses and seasonal booster doses, all delivered via the EPI clinics, which was the preferred strategy for delivery of RTS,S/AS01 E in Mali identified during the national workshop. Participants recommended that supportive interventions, including communications and mobilisation, would be needed for this strategy to achieve required coverage. Conclusions Four delivery strategies were identified for administration of RTS,S/AS01 E alongside SMC in countries with seasonal malaria transmission. Components of these delivery strategies were defined as the vaccination schedule, and the delivery system(s) plus the supportive interventions needed for the strategies to be effective. Further implementation research and evaluation is needed to explore how, where, when and what effective coverage is achievable via these new strategies and their supportive interventions
Environmental health · Malaria · Malaria vaccine · Plasmodium falciparum · Public health · Vaccination · Global Maternal and Child Health · Malaria Research and Control · Medicine · Nursing · Vaccine Coverage and Hesitancy · Immunology
How We Design Feasibility Studies
Theory of Change
Using the framework method for the analysis of qualitative data in multi-disciplinary health research
Short message service (SMS) reminders for childhood immunisation in low-income and middle-income countries
One year of campaigns in Cameroon
The craft of interviewing in realist evaluation
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