Factors associated with prolonged viral shedding in older patients infected with Omicron BA.2.2
Bibliographic Data
| ID | 22070407 |
|---|---|
| Authors | Weijie Zhong (0009-0004-2041-0987, Shanghai Jiao Tong University), Xiaosheng Yang (0000-0003-1535-3282, Shanghai Jiao Tong University), Xiufeng Jiang (Shanghai Jiao Tong University), Zhixin Duan (0000-0001-9681-4428, Shanghai Jiao Tong University), Wei Wang (0000-0001-5806-2368, Shanghai Jiao Tong University), Zhaoliang Sun, Zhao-Liang Sun (Shanghai Jiao Tong University), Wanghao Chen (Shanghai Jiao Tong University), Wenchuan Zhang (0000-0001-9632-6424, Shanghai Jiao Tong University), Jie Xu (0000-0001-5291-5198, Shanghai Jiao Tong University), Juan Cheng (0000-0003-2705-8766, Shanghai Jiao Tong University, corresponding author), Xiaoling Yuan (0000-0002-0795-0266, Shanghai Jiao Tong University, corresponding author), Yi Li (0000-0002-3875-3513, Shanghai Jiao Tong University, corresponding author) |
| Year | 2023 |
| Volume | 10 |
| Pages | 1087800-1087800 |
| Publication date | 2023-01-12 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2022.1087800 |
| PMID | 36711364 |
| OpenAlex | W4315782147 |
| Language | EN |
| Citations received | 3 |
| References cited | 31 |
Background This study explores the risk factors associated with viral shedding time in elderly Chinese patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron. Methods Participants infected with SARS-CoV-2 omicron were enrolled in a retrospective study, and divided into two groups according to shedding time (≥10 days, “late clearance group” and <10 days, “early clearance group”). Results A total of 180 patients were enrolled in the study (88 early, 92 late), with a median viral shedding time of 10 days and a mean age of 77.02 years. Prolonged SARS-CoV-2 omicron shedding was associated with old age ( p = 0.007), lack of vaccination ( p = 0.001), delayed admission to hospital after onset of diagnosis ( p = 0.001), D-dimer ( p = 0.003), and methylprednisolone treatment ( p = 0.048). In multivariate analysis, vaccination (OR, 0.319, 95% CI, 0.130–0.786, p = 0.013), Paxlovid (OR, 0.259, 95% CI, 0.104–0.643, p = 0.004), and time from onset of diagnosis to admission (OR, 1.802, 95% CI, 1.391–2.355, p = 0.000) were significantly associated with viral clearance. Conclusions Time from onset of diagnosis to hospitalization, lack of treatment with Paxlovid, and lack of vaccination were independent risk factors in elderly Chinese patients infected with SARS-CoV-2 omicron for prolonged viral shedding
Viral Shedding · Virus · COVID-19 Clinical Research Studies · Long-Term Effects of COVID-19 · Medicine · SARS-CoV-2 and COVID-19 Research · Virology
| Citations per year | 1 |
|---|---|
| Citation span | 2023 - 2024 (2) |
| Highly cited | No |