The Disease Severity and Clinical Outcomes of the Sars-CoV-2 Variants of Concern
Bibliographic Data
| ID | 22088394 |
|---|---|
| Authors | Lixin Lin (0000-0001-8339-5965, Hong Kong Polytechnic University), Ying Liu (0000-0001-5584-7805, Xiamen University), Xiujuan Tang (Shenzhen Center for Disease Control and Prevention), Daihai He (0000-0003-3253-654X, Hong Kong Polytechnic University, corresponding author) |
| Year | 2021 |
| Volume | 9 |
| Pages | 775224-775224 |
| Publication date | 2021-11-30 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Frontiers in Public Health (JOURNAL) |
| Journal identifiers | ISSN: 2296-2565 • E-ISSN: 2296-2565 |
| Publisher | Frontiers Media SA (PUBLISHER • CH) |
| DOI | 10.3389/fpubh.2021.775224 |
| PMID | 34917580 |
| OpenAlex | W3217290471 |
| Language | EN |
| Citations received | 15 |
| References cited | 47 |
With the continuation of the pandemic, many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have appeared around the world. Owing to a possible risk of increasing the transmissibility of the virus, severity of the infected individuals, and the ability to escape the antibody produced by the vaccines, the four SARS-CoV-2 variants of Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2) have attracted the most widespread attention. At present, there is a unified conclusion that these four variants have increased the transmissibility of SARS-CoV-2, but the severity of the disease caused by them has not yet been determined. Studies from June 1, 2020 to October 15, 2021 were considered, and a meta-analysis was carried out to process the data. Alpha, Beta, Gamma, and Delta variants are all more serious than the wild-type virus in terms of hospitalization, ICU admission, and mortality, and the Beta and Delta variants have a higher risk than the Alpha and Gamma variants. Notably, the random effects of Beta variant to the wild-type virus with respect to hospitalization rate, severe illness rate, and mortality rate are 2.16 (95% CI: 1.19–3.14), 2.23 (95% CI: 1.31–3.15), and 1.50 (95% CI: 1.26–1.74), respectively, and the random effects of Delta variant to the wild-type virus are 2.08 (95% CI: 1.77–2.39), 3.35 (95% CI: 2.5–4.2), and 2.33 (95% CI: 1.45–3.21), respectively. Although, the emergence of vaccines may reduce the threat posed by SARS-CoV-2 variants, these are still very important, especially the Beta and Delta variants
Disease · Mortality rate · Pandemic · Severity of illness · Virus · Animal Virus Infections Studies · Medicine · SARS-CoV-2 and COVID-19 Research · SARS-CoV-2 detection and testing · Internal Medicine · Virology
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| Unique citing works | 15 |
|---|---|
| Citations per year | 0.31 |
| Citation span | 1978 - 2026 (49) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 15 |