Aqueous Polygalae Radix extract (PRE) prolongs the lifespan of C. elegans and alleviates D-galactose-induced oxidative stress in the mouse liver and brain by modulating PPARγ/Mapk

Bibliographic Data

ID22917554
AuthorsJiaqi Zhang (0000-0002-7999-8330, Jilin University, corresponding author), Wenxue Zheng (Jilin University), Zhengjie Zhou (0000-0001-8329-6086, Jilin University), Yu An (0000-0002-4818-4641, Jilin University), Yiming An (0000-0002-2269-0327), Haoyu Zheng (0000-0003-1319-6439, Jilin University), Yanan Zhang (0000-0003-3836-4232, Jilin University), Yu Wei (0000-0003-3809-1449, First Bethune Hospital of Jilin University), Yuchen Wei (0000-0002-6821-4617), Qianhua Zhang (First Bethune Hospital of Jilin University), Jingtong Zheng (0000-0003-4615-3734, Jilin University), Fang Wang (0000-0001-7353-9080, Jilin University)
Year2025
Volume348
Pages119878
Publication date2025-05-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.119878
PMID40287113
OpenAlexW4409753525
LanguageEN
References cited56

PRE delays aging and resists oxidative stress in organisms; it may act by regulating the PPARγ/MAPK signaling pathway and the intestinal flora. The efficacy and mechanism of PRE against oxidative stress were elucidated using RNA-seq and 16S rDNA sequencing, providing a reference for antiaging and aging-related diseases.

Anti oxidant · Antioxidant · Aqueous extract · Biology · Botany · Galactose · Kinase · MAPK/ERK pathway · Oxidative stress · Radix (gastropod) · Traditional medicine · Antioxidants, Aging, Portulaca oleracea · Biochemistry · Chemistry · Diet, Metabolism, and Disease · Medicine · Pharmacology · Phytoestrogen effects and research

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