Sample size used to validate a scale

A review of publications on newly-developed patient reported outcomes measures

Bibliographic Data

ID23317217
AuthorsEmmanuelle Anthoine (0000-0003-0411-5289, Centre Hospitalier Universitaire de Nantes, corresponding author), L Moret (0000-0003-1285-6394, Hôpital Saint-Jacques), Antoine Regnault (0000-0001-8234-2896, Mapi Research Trust), Véronique Sébille (0000-0002-0780-7742, Sciences, Philosophie, Histoire), Jean-Benoit Hardouin (0000-0001-8664-623X, Sciences, Philosophie, Histoire)
Year2014
Volume12
Issue1
Pages176-176
Publication date2014-12-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueHealth and Quality of Life Outcomes (JOURNAL)
Journal identifiersISSN: 1477-7525 • E-ISSN: 1477-7525
PublisherSpringer Science and Business Media LLC (PUBLISHER)
DOI10.1186/s12955-014-0176-2
PMID24400663
PMCIDPMC4275948
OpenAlexW2102895650
LanguageEN
Citations received105
References cited36

BACKGROUND: Although recommended for use in studies investigating falls in the elderly, the European Quality of Life Group instrument, EQ-5D, has not been widely used to assess the impact of falls on quality of life. The aim of this study was to investigate the association of single and frequent falls with EQ-5D rated quality of life in a sample of German community-dwelling seniors in primary care suffering a variety of concurrent chronic diseases and conditions. METHODS: In a cross-sectional study, a sample of community-dwelling seniors aged ≥ 72 years was interviewed by means of a standardised telephone interview. According to the number of self-reported falls within twelve months prior to interview, participants were categorised into one of three fall categories: no fall vs. one fall vs. two or more falls within twelve months. EQ-5D values as well as other characteristics were compared across the fall categories. Adjustments for a variety of concurrent chronic diseases and conditions and further variables were made by using multiple linear regression analysis, with EQ-5D being the target variable. RESULTS: In total, 1,792 participants (median age 77 years; 53% female) were analysed. The EQ-5D differed between fall categories. Participants reporting no fall had a mean EQ-5D score of 81.1 (standard deviation [s.d.]: 15.4, median: 78.3), while participants reporting one fall (n = 265; 14.8%) and participants with two or more falls (n = 117; 6.5%) had mean total scores of 77.0 (s.d.: 15.8, median: 78.3; mean difference to participants without a fall: -4.1, p < 0.05) and 72.1 (s.d.: 17.6, median: 72.5; mean difference: -9.0, p < 0.05), respectively. The mean difference between participants with one fall and participants with two or more falls was -4.9 (p < 0.05). Under adjustment for a variety of chronic diseases and conditions, the mean decrease in the total EQ-5D score was about -1.0 score point for one fall and about -2.5 points for two or more falls within twelve months. In quantity, this decrease is comparable to other chronic diseases adjusted for. Among the variables with the greatest negative association with EQ-5D ratings in multivariate analysis were depression and fear of falling. CONCLUSIONS: The findings suggest that falls are negatively associated with EQ-5D rated quality of life independent of a variety of chronic diseases and conditions.

Construct validity · Data extraction · Geography · MEDLINE · Psychometrics · Sample (material) · Sample size determination · Scale (ratio) · Statistics · Balance, Gait, and Falls Prevention · Chronic Disease Management Strategies · Clinical Psychology · Health Systems, Economic Evaluations, Quality of Life · Mathematics · Medicine · Psychology

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