Intellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter
Bibliographic Data
| ID | 23366258 |
|---|---|
| Authors | Richard L Canfield (0000-0002-4225-7029, Cornell University), Charles Henderson (0000-0003-0334-6739, Cornell University), Charles R Henderson, Deborah A Cory-Slechta, Deborah A Cory‐Slechta (0000-0002-3789-8606, University of Rochester), Cameron Cox (0000-0003-4076-581X), Christopher Cox (0000-0001-7406-5948, Health and Human Development (2HD) Research Network), Todd A Jusko (0000-0002-3194-6718, University of Washington), B P Lanphear (0000-0003-2598-5574, Cincinnati Children's Hospital Medical Center) |
| Year | 2003 |
| Volume | 348 |
| Issue | 16 |
| Pages | 1517-1526 |
| Publication date | 2003-04-17 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | New England Journal of Medicine (JOURNAL) |
| Journal identifiers | ISSN: 0028-4793 • E-ISSN: 1533-4406 |
| Publisher | Massachusetts Medical Society (PUBLISHER • US) |
| DOI | 10.1056/nejmoa022848 |
| PMID | 12700371 |
| PMCID | PMC4046839 |
| OpenAlex | W2146334297 |
| Language | EN |
| Citations received | 123 |
| References cited | 38 |
BACKGROUND: Despite dramatic declines in children's blood lead concentrations and a lowering of the Centers for Disease Control and Prevention's level of concern to 10 microg per deciliter (0.483 micromol per liter), little is known about children's neurobehavioral functioning at lead concentrations below this level. METHODS: We measured blood lead concentrations in 172 children at 6, 12, 18, 24, 36, 48, and 60 months of age and administered the Stanford-Binet Intelligence Scale at the ages of 3 and 5 years. The relation between IQ and blood lead concentration was estimated with the use of linear and nonlinear mixed models, with adjustment for maternal IQ, quality of the home environment, and other potential confounders. RESULTS: The blood lead concentration was inversely and significantly associated with IQ. In the linear model, each increase of 10 microg per deciliter in the lifetime average blood lead concentration was associated with a 4.6-point decrease in IQ (P=0.004), whereas for the subsample of 101 children whose maximal lead concentrations remained below 10 microg per deciliter, the change in IQ associated with a given change in lead concentration was greater. When estimated in a nonlinear model with the full sample, IQ declined by 7.4 points as lifetime average blood lead concentrations increased from 1 to 10 microg per deciliter. CONCLUSIONS: Blood lead concentrations, even those below 10 microg per deciliter, are inversely associated with children's IQ scores at three and five years of age, and associated declines in IQ are greater at these concentrations than at higher concentrations. These findings suggest that more U.S. children may be adversely affected by environmental lead than previously estimated.
Blood lead level · Confidence interval · Confounding · Intelligence quotient · Lead (geology) · Lead exposure · Liter · Psychiatry · Tasa · Heavy Metal Exposure and Toxicity · Heavy metals in environment · Internal Medicine · Medicine · Trace Elements in Health · Pediatrics
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| Unique citing works | 123 |
|---|---|
| Citations per year | 5,59 |
| Citation span | 2004 - 2026 (23) |
| Citation velocity | current |
| Highly cited | Yes |
| Citation types | Neutral: 107 |