Practical and Conceptual Challenges in Measuring Antiretroviral Adherence
Bibliographic Data
| ID | 23375182 |
|---|---|
| Authors | Karina M Berg (0000-0001-7536-3760, Albert Einstein College of Medicine), Julia H Arnsten (0000-0002-7741-1567, Albert Einstein College of Medicine) |
| Year | 2006 |
| Volume | 43 |
| Issue | Supplement 1 |
| Pages | S79-S87 |
| Publication date | 2006-12-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | JAIDS Journal of Acquired Immune Deficiency Syndromes (JOURNAL) |
| Journal identifiers | ISSN: 1525-4135 • E-ISSN: 1944-7884 |
| Publisher | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/01.qai.0000248337.97814.66 |
| PMID | 17133207 |
| PMCID | PMC2866146 |
| OpenAlex | W2042509763 |
| Language | EN |
| Citations received | 57 |
| References cited | 86 |
Accurate measurement of antiretroviral adherence is essential for targeting and rigorously evaluating interventions to improve adherence and prevent viral resistance. Across diseases, medication adherence is an individual, complex, and dynamic human behavior that presents unique measurement challenges. Measurement of medication adherence is further complicated by the diversity of available measures, which have different utility in clinical and research settings. Limited understanding of how to optimize existing adherence measures has hindered progress in adherence research in HIV and other diseases. Although self-report is the most widely used adherence measure and the most promising for use in clinical care and resource-limited settings, adherence researchers have yet to develop evidence-based standards for self-reported adherence. In addition, the use of objective measures, such as electronic drug monitoring or pill counts, is limited by poor understanding of the source and magnitude of error biasing these measures. To address these limitations, research is needed to evaluate methods of combining information from different measures. The goals of this review are to describe the state of the science of adherence measurement, to discuss the advantages and disadvantages of common adherence measurement methods, and to recommend directions for improving antiretroviral adherence measurement in research and clinical care.
Family medicine · Human immunodeficiency virus (HIV) · Intensive care medicine · Medication adherence · MEDLINE · Pill · Psychiatry · Psychological intervention · Computer Science · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Medication Adherence and Compliance · Medicine · Pharmacology
An HIV Preexposure Prophylaxis Demonstration Project and Safety Study for Young MSM
Social Support Mitigates Negative Impact of Food Insecurity on Antiretroviral Adherence Among Postpartum Women in Western Kenya
Correlation of Adherence by Pill Count, Self-report, Mems and Plasma Drug Levels to Treatment Response Among Women Receiving ARV Therapy for PMTCT in Kenya
Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance
Development and validation of the WebAd-Q Questionnaire to monitor adherence to HIV therapy
Measuring adherence to antiretroviral therapy in northern Tanzania
Pharmacy refill adherence outperforms self-reported methods in predicting HIV therapy outcome in resource-limited settings
Adherence to Highly Active Antiretroviral Therapy (Haart)
Self-report measures of medication adherence behavior
Children and Adolescents with Perinatal HIV-1 Infection
Evaluation of smartphone APP-based case-management services among antiretroviral treatment-naïve HIV-positive men who have sex with men
Applying convergent parallel mixed methods design to investigate medication adherence among people living with HIV in resource-limited settings
Standard Measures are Inadequate to Monitor Pediatric Adherence in a Resource-Limited Setting
Correlation Between Pill Counts and Biologic Effects in an HIV-1 Prevention Clinical Trial
Monitoring Microbicide Gel Use with Real-Time Notification of the Container’s Opening Events
Measuring Adherence to Antiretroviral Treatment
Comprehensive Evaluation of Caregiver-Reported Antiretroviral Therapy Adherence for HIV-Infected Children
The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV)
Reliability and Validity of a Brief Self-Report Adherence Measure among People with HIV Experiencing Homelessness and Mental Health or Substance Use Disorders
A Self-Reported Adherence Measure to Screen for Elevated HIV Viral Load in Pregnant and Postpartum Women on Antiretroviral Therapy
Lack of Association between Retrospectively Collected Pharmacy Refill Data and Electronic Drug Monitoring of Antiretroviral Adherence
Effect of Computer-Assisted Interviewing on Self-Reported Sexual Behavior Data in a Microbicide Clinical Trial
Feasibility of Real Time Medication Monitoring Among HIV Infected and TB Patients in a Resource-Limited Setting
Behavioral Intervention Improves Treatment Outcomes Among HIV-Infected Individuals Who Have Delayed, Declined, or Discontinued Antiretroviral Therapy
Comparison of Antiretroviral Adherence Questions
Feasibility, Performance, and Acceptability of the WisebagTM for Potential Monitoring of Daily Gel Applicator Use in Durban, South Africa
Contingency Management for Integrated Harm Reduction Among Men Who Have Sex with Men Who Use Methamphetamine in Los Angeles
What Time is it? Adherence to Antiretroviral Therapy in Ethiopia
Association of Adolescent- and Caregiver-Reported Antiretroviral Therapy Adherence with HIV Viral Load Among Perinatally-infected South African Adolescents
Factors Associated with Adherence and Concordance Between Measurement Strategies in an HIV Daily Oral Tenofovir/Emtricitibine as Pre-exposure Prophylaxis (Prep) Clinical Trial, Botswana, 2007–2010
Moving Antiretroviral Adherence Assessments to the Modern Era
Randomized Controlled Trial of Automated Directly Observed Therapy for Measurement and Support of PrEP Adherence Among Young Men Who have Sex with Men
Correlates of Stigma among Rural Indian Women Living with HIV/Aids
Summary Measures of Adherence Using Pill Counts in Two HIV Prevention Trials
Pesky metrics
How late is too late? Timeliness to scheduled visits as an antiretroviral therapy adherence measure in Nairobi, Kenya and Lusaka, Zambia
Comparison of HIV-positive women with children and without children accessing HIV care and treatment in the IeDEA Central Africa cohort
Treatment partners and adherence to Haart in Central Mozambique
Comparison of the predictive performance of adherence measures for virologic failure detection in people living with HIV
Does switching from multiple to single-tablet regimen containing the same antiretroviral drugs improve adherence? A group-based trajectory modeling analysis
Female adherence self-efficacy before and after couple HIV testing and counseling within Malawi’s Option B+ program
Factors associated with adherence to antiretroviral therapy among adolescents living with HIV/Aids in low- and middle-income countries
Sub-optimal adherence to combination anti-retroviral therapy and its associated factors according to self-report, clinician-recorded and pharmacy-refill assessment methods among HIV-infected adults in Addis Ababa
Assessing the impact of implementing multiple adherence measures to antiretroviral therapy from dispensing data
Barriers to antiretroviral adherence in HIV-positive patients receiving free medication in Kayunga, Uganda
Counseling for improving adherence to antiretroviral treatment
Randomized controlled trial of a pictorial aid intervention for medication adherence among HIV-positive patients with comorbid diabetes or hypertension
Relationship between viral load and self-report measures of medication adherence among youth with perinatal HIV infection
Aspectos relacionados à utilização de antirretrovirais em pacientes de alta complexidade no estado do Rio de Janeiro, Brasil
Monitoramento e avaliação da adesão ao tratamento antirretroviral para HIV/aids
Conceptualisations of masculinity and self-reported medication adherence among HIV-positive Latino men in Los Angeles, California, USA
Theorizing “Big Events” as a potential risk environment for drug use, drug-related harm and HIV epidemic outbreaks
Comparison of Pharmacy Claims and Electronic Pill Bottles for Measurement of Medication Adherence Among Myocardial Infarction Patients
Self-Report Adherence Measures in Chronic Illness
Medication Acquisition and Self-Reported Adherence in Veterans With Hypertension
Monitoring adherence to antiretroviral treatment in Brazil
Utilização de registros de dispensação de medicamentos na mensuração da adesão
The assessment of refill compliance using pharmacy records
Better physician-patient relationships are associated with higher reported adherence to antiretroviral therapy in patients with HIV infection
The Consistency of Adherence to Antiretroviral Therapy Predicts Biologic Outcomes for Human Immunodeficiency Virus–Infected Persons in Clinical Trials
Measuring Adherence to Antiretroviral Therapy in a Diverse Population Using a Visual Analogue Scale
Multiple Validated Measures of Adherence Indicate High Levels of Adherence to Generic HIV Antiretroviral Therapy in a Resource-Limited Setting
Randomized Controlled Trial of Audio Computer-assisted Self-Interviewing
Self-Report Measures of Antiretroviral Therapy Adherence
Responses to a 1 month self-report on adherence to antiretroviral therapy are consistent with electronic data and virological treatment outcome
Trust and the Acceptance of and Adherence to Antiretroviral Therapy
Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
Antiretroviral Therapy Adherence and Viral Suppression in HIV‐Infected Drug Users
Relationship of gender, depression, and health care delivery with antiretroviral adherence in HIV-infected drug users
A Comparison Study of Multiple Measures of Adherence to HIV Protease Inhibitors
Risk Behaviors by Audio Computer-Assisted Self-Interviews among HIV-Seropositive and HIV-Seronegative Injection Drug Users
A computer-based assessment detects regimen misunderstandings and nonadherence for patients on HIV antiretroviral therapy
A randomized comparison of two instruments for measuring self-reported antiretroviral adherence
Measuring medication adherence
Adherence to combined Lamivudine+Zidovudine versus individual components
The Case adherence index
Comparing Objective Measures of Adherence to HIV Antiretroviral Therapy
Patient?Clinician Relationships and Treatment System Effects on HIV Medication Adherence
Use of Electronic Monitoring Devices to Measure Antiretroviral Adherence
Variations in Patterns of Highly Active Antiretroviral Therapy (Haart) Adherence
Measuring Adherence Among HIV-Infected Persons
Conducting Cognitive Interviews to Understand Question-Response Limitations
Cognitive psychology and self-reports
A Dialectic on Validity
A General Method of Compliance Assessment Using Centralized Pharmacy Records
Patient Adherence and Medical Treatment Outcomes
Variations in Patients’ Adherence to Medical Recommendations
Response to Hays et al and McHorney and Cohen
| Unique citing works | 57 |
|---|---|
| Citations per year | 3,17 |
| Citation span | 2008 - 2026 (19) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 52 |