Familial predisposition and susceptibility to the effect of other risk factors for myocardial infarction
Bibliographic Data
| ID | 11172174 |
|---|---|
| Authors | M Hippe (Copenhagen University Hospital), Jørgen Vestbo (0000-0001-6355-6362, Copenhagen University Hospital), Hans Ole Hein (Copenhagen University Hospital), K Borch-Johnsen, K Borch‐Johnsen (Copenhagen University Hospital), Gorm Jensen (0000-0002-9866-3800, Copenhagen University Hospital), T I A SØRENSEN (Copenhagen University Hospital), T I Sørensen |
| Year | 1999 |
| Volume | 53 |
| Issue | 5 |
| Pages | 269-276 |
| Publication date | 1999-05-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Epidemiology and Community Health (JOURNAL) |
| Journal identifiers | ISSN: 0143-005X • E-ISSN: 1470-2738 |
| Publisher | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/jech.53.5.269 |
| PMID | 10396532 |
| OpenAlex | W1965714567 |
| Language | EN |
| Citations received | 2 |
| References cited | 33 |
STUDY OBJECTIVES: To assess if familial predisposition to myocardial infarction (MI) is an indicator of increased susceptibility to the effect of other established risk factors. The study assessed whether a family history of MI modifies the effect of arterial blood pressure, plasma cholesterol, high and low density lipoprotein cholesterol, % triglycerides, diabetes mellitus, body mass index, height, smoking habits, alcohol intake, physical activity level, and educational level on the incidence of MI. DESIGN: Prospective population based cohort study of cardiovascular risk and risk factors with follow up of MI by record linkage with the Cause of Death Register and The National Hospital Discharge Register until 1994. SETTING: The Copenhagen Centre for Prospective Population Studies, where data from three Danish studies are integrated. PARTICIPANTS: Subjects were 24,664 people aged 20-93, examined between 1976 and 1987. MAIN RESULTS: A total of 1763 new cases of MI occurred during 293,559 person years of observation. All risk factors, including family history of MI reported by 4012 subjects, were, as expected, associated with incidence of MI. With a few inconsistent exceptions we found no significant interactions between family history of MI and cardiovascular risk factors in their effect on MI. CONCLUSIONS: The familial predisposition to MI does not consistently modify the effect of other risk factors on the risk of MI. However, subjects with a family history of MI may still be regarded as an appropriate target group for screening for cardiovascular risk and intervention against other risk factors
Blood pressure · Body mass index · Cohort study · Disease · Environmental health · Family history · Genetic predisposition · Incidence (geometry) · Myocardial infarction · Population · Prospective cohort study · Risk factor · Acute Myocardial Infarction Research · Diabetes, Cardiovascular Risks, and Lipoproteins · Genetic Associations and Epidemiology · Internal Medicine · Medicine
Influences of Cardiorespiratory Fitness and Other Precursors on Cardiovascular Disease and All-Cause Mortality in Men and Women
National Trends in Educational Differentials in Mortality
Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
Cardiovascular risk factor profile in subjects with familial predisposition to myocardial infarction in Denmark
Height and the risk of acute myocardial infarction in Italian women
Statistical Models in Epidemiology
| Unique citing works | 2 |
|---|---|
| Citations per year | 0.13 |
| Citation span | 2011 - 2015 (5) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 2 |