Acetylcholinesterase Inhibitor in Combination With Cognitive Training in Older Adults
Bibliographic Data
| ID | 12440893 |
|---|---|
| Authors | Jerome A Yesavage (0000-0002-7390-3281, corresponding author), Leah Friedman (0009-0004-8507-7986), J Wesson Ashford (0000-0001-9600-6471), Helena C Kraemer (0000-0003-3843-2637), M Mumenthaler, M S Mumenthaler, Art Noda, Jennifer Hoblyn (0000-0002-9393-4763) |
| Year | 2008 |
| Volume | 63 |
| Issue | 5 |
| Pages | P288-P294 |
| Publication date | 2008-09-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | The Journals of Gerontology Series B (JOURNAL) |
| Journal identifiers | ISSN: 1079-5014 • E-ISSN: 1758-5368 |
| Publisher | Oxford University Press (OUP) (PUBLISHER) |
| DOI | 10.1093/geronb/63.5.p288 |
| PMID | 18818443 |
| OpenAlex | W2162709940 |
| Language | EN |
| References cited | 30 |
To determine if donepezil, an acetylcholinesterase (AChE) inhibitor, improved the assimilation of cognitive training by older adults with memory complaints, we gave 168 nondemented, community-dwelling volunteers with memory complaints either 5 mg of donepezil (Aricept) or placebo daily for 6 weeks in a randomized, double-blind, placebo-controlled trial. The dosage rose to 10 mg daily for another 6 weeks before a 2-week course of cognitive training and was maintained for the remainder of a year. Cognitive training improved performance; donepezil was well tolerated. However, there were no significant benefits of donepezil compared with placebo. An additional dose-ranging study with a starting dose of 5 mg a day suggests that the high dose was not the reason. Physiological tolerance may occur with chronic donepezil treatment and may increase AChE levels; this may be why short-term studies have shown the benefit of AChE inhibitor use in nondemented participants whereas chronic use has failed to enhance cognition
Acetylcholinesterase · Acetylcholinesterase inhibitor · Aché · Cognition · Cognitive Training · Dementia · Donepezil · Placebo · Psychiatry · Randomized controlled trial · Blood Pressure and Hypertension Studies · Chemistry · Dementia and Cognitive Impairment Research · Medicine · Memory and Neural Mechanisms · Psychology · Internal Medicine · Pharmacology
| Citation velocity | historical |
|---|---|
| Highly cited | No |