Serum homocysteine and folate concentrations among a US cohort of adolescents before and after folic acid fortification
Bibliographic Data
| ID | 15091530 |
|---|---|
| Authors | Daniel A Enquobahrie (0000-0001-9844-0597, University of Washington, corresponding author), Henry A Feldman (0000-0002-1748-0894, Boston Children's Hospital), Deanna H Hoelscher, Deanna M Hoelscher (0000-0002-0910-5031, The University of Texas Health Science Center at Houston), Lyn M Steffen (0000-0002-4053-6729, Minnesota Department of Health), Larry S Webber (Tulane University), Michelle Zive (0000-0001-7777-3376, University of California San Diego), Michelle M Zive, Eric B Rimm (0000-0002-1402-7250, Harvard University), Meir J Stampfer (0000-0001-8865-935X, Harvard University), Stavroula K Osganian (0000-0001-5446-9160, Harvard University) |
| Year | 2012 |
| Volume | 15 |
| Issue | 10 |
| Pages | 1818-1826 |
| Publication date | 2012-10-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Public Health Nutrition (JOURNAL) |
| Journal identifiers | ISSN: 1368-9800 • E-ISSN: 1475-2727 |
| Publisher | Cambridge University Press (CUP) (PUBLISHER) |
| DOI | 10.1017/s1368980012002984 |
| PMID | 22974678 |
| PMCID | PMC3638807 |
| OpenAlex | W2134102924 |
| Language | EN |
| Citations received | 1 |
| References cited | 41 |
Objective We assessed serum homocysteine (tHcy) and folate concentrations among US adolescents before and after fortification of cereal-grain products with folic acid, and associations with demographic, behavioural and physiological factors. Design Observational study conducted among participants of a randomized trial. Setting The Child and Adolescent Trial for Cardiovascular Health (CATCH) study. Subjects Adolescents ( n 2445) in grades 8 (pre-fortification, mean age 14 years) and 12 (post-fortification, mean age 18 years). Results Average serum concentrations of tHcy, folate and vitamin B 6 increased by 17 %, 16 % and 14 %, respectively, while serum concentrations of vitamin B 12 decreased by 11 % post-fortification. Folic acid fortification provided, on average, an additional intake of 118 μg folate/d. Male sex ( P P = 0·0008) were associated with significantly greater increases in tHcy concentration, while increases in BMI ( P = 0·006) and serum folate concentration ( P P P P P = 0·001) were associated with significantly greater increases in serum folate concentrations. From grade 8 to grade 12, the upward age trend in serum tHcy concentration was uninterrupted in its course ( P > 0·50); whereas serum folic acid concentration showed a downward trend that incurred a discrete jump upward (17 % higher; P v . females ( P Conclusions Fortification had a significant impact on improving folate status but not serum tHcy concentrations among US adolescents
Cohort · folic acid · Food fortification · Fortification · Homocysteine · Vitamin · Vitamin B12 · Chemistry · Esophageal and GI Pathology · Folate and B Vitamins Research · Medicine · Nutrition and Health in Aging · Food Science · Internal Medicine · Physiology
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,07 |
| Citation span | 2012 - 2012 (1) |
| Citation velocity | historical |
| Highly cited | No |
| Citation types | Neutral: 1 |