Reduced pattern similarity in brain activation during orthographic processing in children with developmental dyslexia

Bibliographic Data

ID21425543
AuthorsYu Wu (0000-0002-1537-5492), Concepción Álvaro Bermejo (corresponding author), Guoyan Feng (0000-0001-7086-3520), Xiaohui Yan (0000-0001-8425-5032), Kyle Perkins (0000-0002-0184-7399), Lanfang Liu (0000-0002-1448-9009), Xin Yan (0000-0002-6858-9152), Fan Cao (0000-0002-3786-1600)
Year2022
Volume235
Issue546
Pages105201
Publication date2022-12-01
Open AccessYes
TypeARTICLE
VenueBrain and Language (JOURNAL)
Journal identifiersISSN: 0093-934X • E-ISSN: 1090-2155
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.bandl.2022.105201
OpenAlexW36368117
LanguageEN
Citations received1
References cited59

Intra-individual variability of neural response has been found to be negatively associated with cognitive proficiency and automaticity. However, whether developmental dyslexia (DD) is marked by greater intra-individual neural variability remains unclear. Using a multivariate approach and dual-control group design, the current study aims to examine whether the pattern similarity of brain activation during a visual spelling task is abnormal in children with DD compared to age control and reading control children. We found that there was reduced intra-subject pattern similarity at the left occipito-temporal regions in children with DD than both control groups, suggesting a neural signature of DD. Furthermore, we found that pattern similarity was positively associated with stability of reaction time and reading fluency in both children with DD and typical control children, suggesting that neural stability supports behavioral stability and automaticity during reading

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