Initial sequencing and analysis of the human genome

Bibliographic Data

ID23328009
AuthorsLauren Linton (Whitehead Institute for Biomedical Research), Bruce W Birren (0000-0001-6971-945X, Whitehead Institute for Biomedical Research), Eric S Lander (0000-0003-2662-4631, Whitehead Institute for Biomedical Research, corresponding author), Lauren M Linton, Bruce Birren, Jennifer Baldwin (0000-0001-7830-7270, Whitehead Institute for Biomedical Research), Chad Nusbaum (0000-0002-2777-1708, Whitehead Institute for Biomedical Research), Michael C Zody (0000-0001-6594-7199, Whitehead Institute for Biomedical Research), Jennifer L Baldwin (0000-0002-4038-7911), Maura P Doyle (0000-0003-1386-3780, Whitehead Institute for Biomedical Research), Keri Devon (Whitehead Institute for Biomedical Research), William W Fitzhugh (Whitehead Institute for Biomedical Research), Ken Dewar (0000-0003-2688-138X, Whitehead Institute for Biomedical Research), Michael Doyle (0000-0003-2083-8575), William Fitzhugh, Roel Funke (Whitehead Institute for Biomedical Research), Katrina L Harris (Whitehead Institute for Biomedical Research), Diane Gage (Whitehead Institute for Biomedical Research), Katrina Harris, John G Howland (0000-0003-3326-7118, Whitehead Institute for Biomedical Research), Andrew Heaford (Whitehead Institute for Biomedical Research), John Howland, Jessica A Lehoczky (0000-0002-9210-2922, Whitehead Institute for Biomedical Research), Lisa Kann (0000-0002-3350-0963, Whitehead Institute for Biomedical Research), R Paul Levine (Whitehead Institute for Biomedical Research), Jessica Lehoczky, Rosie LeVine, Paul Mcewan (0000-0001-6097-1528, Whitehead Institute for Biomedical Research), James C Meldrim (Whitehead Institute for Biomedical Research), Kevin McKernan (0000-0002-3908-1122, Whitehead Institute for Biomedical Research), James Meldrim, Wright Morris (0000-0002-9622-1179, Whitehead Institute for Biomedical Research), Jill P Mesirov (0000-0002-9755-2818, Whitehead Institute for Biomedical Research), Cher Miranda (Whitehead Institute for Biomedical Research), Jerome W Naylor (Whitehead Institute for Biomedical Research), William Morris, Jerome Naylor, Christina Raymond (University of Washington), Mark Rosetti (Whitehead Institute for Biomedical Research), Ralph Santos (Whitehead Institute for Biomedical Research), Andrew Sheridan (Whitehead Institute for Biomedical Research), Nikola M Stojanović (0000-0002-0124-3501, Whitehead Institute for Biomedical Research), Carrie Sougnez (Whitehead Institute for Biomedical Research), Nicole Stange-Thomann (Whitehead Institute for Biomedical Research), Nikola Stojanović (0000-0002-9921-6391), Aravind Subramanian (0009-0006-5468-5916, Whitehead Institute for Biomedical Research), Dudley Wyman (Whitehead Institute for Biomedical Research), The Sanger Centre, Jane Rogers (Wellcome Sanger Institute), John Sulston (Wellcome Sanger Institute, corresponding author), John H Burton (Wellcome Sanger Institute), Rachael Ainscough, Stephan Beck (0000-0001-5290-2151, Wellcome Sanger Institute), David Bentley (0000-0002-2203-5197, Wellcome Sanger Institute), John Burton (0000-0003-3157-3621), Christopher Clee (Wellcome Sanger Institute), Nigel Carter (Wellcome Sanger Institute), Alan Coulson (Wellcome Sanger Institute), Rebecca Deadman (Wellcome Sanger Institute), Panos Deloukas (0000-0001-9251-070X, Wellcome Sanger Institute), Lindsay French (0000-0001-7279-8582, Wellcome Sanger Institute), Andrew Dunham (Wellcome Sanger Institute), Ian Dunham (0000-0001-8967-7701, Wellcome Sanger Institute), Richard Durbin (0000-0002-9130-1006, Wellcome Sanger Institute), Simon G Gregory (0000-0002-7805-1743, Wellcome Sanger Institute), Ted Hubbard (0000-0002-1767-9318, Wellcome Sanger Institute), Lisa French (0000-0003-2893-9098), Darren Grafham (Wellcome Sanger Institute), A Hunt (0000-0002-1227-0310, Wellcome Sanger Institute), Simon Gregory, Matthew C Jones (0009-0000-9788-0793, Wellcome Sanger Institute), Tim Hubbard, Sean Humphray (Wellcome Sanger Institute), Amanda A McMurray (0000-0001-8237-3289, Wellcome Sanger Institute), Matthew Jones (0000-0002-9272-5687), Christine Lloyd (Wellcome Sanger Institute), Amanda McMurray (0009-0005-7364-6691), Lucy Matthews (Wellcome Sanger Institute), Simon Mercer (Wellcome Sanger Institute), Andrew J Mungall (0000-0002-0905-2742, Wellcome Sanger Institute), Sarah Milne (0000-0003-4209-9435, Wellcome Sanger Institute), R W Plumb (Wellcome Sanger Institute), James C Mullikin (0000-0003-0825-3750, Wellcome Sanger Institute), Mark T Ross (0000-0001-7851-1167, Wellcome Sanger Institute), Andrew Mungall, Robert Plumb, R Waterston (0000-0001-5956-5215, Washington University in St. Louis, corresponding author), Mark Ross (0000-0003-4624-787X), Ratna Shownkeen, Sarah Sims (0000-0002-9505-5498, Wellcome Sanger Institute), Robert H Waterston, Richard K Wilson (0000-0002-1992-1358, Washington University in St. Louis), LaDeana W Hillier (Washington University in St. Louis), John D McPherson (0000-0001-8049-9347, Washington University in St. Louis), Asif Chinwalla (0000-0001-7831-3996, Washington University in St. Louis), Marco A Marra (0000-0001-7146-7175, Washington University in St. Louis), Kymberlie Pepin (0000-0002-2771-309X, Washington University in St. Louis), Elaine R Mardis (0000-0002-5892-1553, Washington University in St. Louis), Warren Gish (Washington University in St. Louis), Lucinda A Fulton (Washington University in St. Louis), Asif T Chinwalla, Kymberlie H Pepin, Warren R Gish, Stephanie L Chissoe (Washington University in St. Louis), Jason Kramer (0000-0002-0098-4084, Washington University in St. Louis), Michael C Wendl (0000-0002-5694-2668, Washington University in St. Louis), Kim D Delehaunty (Washington University in St. Louis), Tracie L Miner (Washington University in St. Louis), D Johnson (0000-0003-2299-2525, Washington University in St. Louis), Andrew Delehaunty (Washington University in St. Louis), Jason B Kramer, Patrick Minx (0000-0003-1179-2173, Washington University in St. Louis), Lisa L Cook (0000-0002-2964-6230, Washington University in St. Louis), Robert S Fulton (0009-0006-6820-3404, Washington University in St. Louis), Douglas L Johnson, Patrick J Minx, Sandra W Clifton (Washington University in St. Louis), Trevor Hawkins (Joint Genome Institute), Elbert Branscomb (0000-0002-7194-4231, Joint Genome Institute), Norman A Doggett (0000-0001-8254-2126, Joint Genome Institute), Jih-Fei Cheng (0000-0001-7315-7613, Joint Genome Institute), Paul Predki (Joint Genome Institute), Paul Richardson (0000-0002-7509-3913, Joint Genome Institute), Anne S Olsen (0000-0003-0431-5723, Joint Genome Institute), Sarah Wenning (Joint Genome Institute), Tom Slezak (Joint Genome Institute), Christopher J Elkin (Joint Genome Institute), Norman Doggett, Edward C Uberbacher (Joint Genome Institute), Jan-Fang Cheng, M E Frazier (Joint Genome Institute), Anne Olsen, Susan Lucas (Joint Genome Institute), Christopher Elkin, Edward Uberbacher, Marvin Frazier, Richard A Gibbs (0000-0002-1356-5698), Donna M Muzny (0000-0002-3055-0359), Steven E Scherer, John B Bouck, Erica J Sodergren, Kim C Worley, Catherine M Rives, James H Gorrell, Michael L Metzker, Susan L Naylor, Raju S Kucherlapati, David L Nelson (0000-0002-1522-0124), George M Weinstock (0000-0002-2997-4592), RIKEN Genomic Sciences Center, Yoshiyuki Sakaki, Asao Fujiyama, Masahira Hattori, Tetsushi Yada, Atsushi Toyoda (0000-0002-0728-7548), Takehiko Itoh, Chiharu Kawagoe, Hidemi Watanabe, Yasushi Totoki, Todd Taylor (0000-0001-7882-2045), Jean Weissenbach, Roland Heilig, William Saurin, Francois Artiguenave, Philippe Brottier, Thomas Bruls, Éric Pelletier (0000-0002-9388-6888), Catherine Robert (0000-0002-8721-7485), Patrick Wincker (0000-0001-7562-3454), André Rosenthal, Matthias Platzer, Gerald Nyakatura, Stefan Taudien, Andreas Rump, GTC Sequencing Center, Douglas R Smith (0000-0002-7194-5787), Lynn Doucette-Stamm, Marc Rubenfield, Keith Weinstock, Hong Mei Lee, JoAnn Dubois, Huanming Yang (0000-0002-0858-3410), Jun Yu (0000-0003-1922-7283), Jian Wang (0000-0001-6128-1254), Guyang Huang, Jun Gu (0009-0006-3712-6186), Leroy Hood, Lee Rowen, Anup Madan, Shizen Qin, Stanford Genome Technology Center, Ronald W Davis (0000-0003-3123-2333), Nancy A Federspiel, A Pia Abola, Michael J Proctor, Bruce A Roe, Feng Chen (0000-0002-9129-7895), Huaqin Pan (0000-0002-7166-108X), Juliane Ramser, Hans Lehrach, Richard Reinhardt, W Richard McCombie, Melissa de la Bastide, Neilay Dedhia, Helmut Blöcker, Klaus Hornischer, Gabriele Nordsiek, Richa Agarwala (0000-0002-5518-9723), L Aravind, Jeffrey A Bailey (0000-0002-6899-8204), Alex Bateman, Serafim Batzoglou, Ewan Birney, Peer Bork (0000-0002-2627-833X), Daniel G Brown, Christopher B Burge, Lorenzo Cerutti, Hsiu-Chuan Chen, Deanna Church, Michele Clamp, Richard R Copley, Tobias Doerks, Sean R Eddy, Evan E Eichler (0000-0002-8246-4014), Terrence S Furey, James Galagan, James G R Gilbert, Cyrus Harmon, Yoshihide Hayashizaki, David Haussler, Henning Hermjakob, Karsten Hokamp (0000-0001-7464-2370), Wonhee Jang, L Steven Johnson, Thomas A Jones (0000-0002-4966-5041), Simon Kasif, Arek Kaspryzk, Scot Kennedy, W James Kent, Paul Kitts, Eugene V Koonin (0000-0003-3943-8299), Ian Korf, David Kulp, Doron Lancet (0000-0001-5424-1393), Todd M Lowe, Aoife McLysaght, Tarjei Mikkelsen, John V Moran, Nicola Mulder, Victor J Pollara, Chris P Ponting (0000-0003-0202-7816), Greg Schuler, Jörg Schultz, Guy Slater, Arian F A Smit, Elia Stupka, Joseph Szustakowki, Danielle Thierry-Mieg, Jean Thierry-Mieg, Lukas Wagner, John Wallis (0000-0001-7171-9264), Raymond Wheeler (0000-0002-8430-7856), Alan Williams (0000-0003-2032-1875), Yuri I Wolf, Kenneth H Wolfe, Shiaw-Pyng Yang, Ru-Fang Yeh, Francis Collins, Mark S Guyer, Jane Peterson, Adam Felsenfeld, Kris A Wetterstrand, Stanford Human Genome Center, Richard M Myers, Jeremy Schmutz, Mark Dickson, Jane Grimwood, David R Cox (0000-0002-9487-3165), Maynard V Olson, Rajinder Kaul, Christopher M Raymond (0000-0002-7165-885X), Christopher Raymond (0000-0002-8702-9337), Nobuyoshi Shimizu, Kazuhiko Kawasaki (0000-0003-1090-5340), Shinsei Minoshima, Glen A Evans, Maria Athanasiou (0009-0000-1723-9761), Roger Schultz, US Department of Energy: Office of Science, Aristides Patrinos, The Wellcome Trust, Michael J Morgan (0000-0002-6687-1269)
Year2001
Volume409
Issue6822
Pages860-921
Publication date2001-02-15
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueNature (JOURNAL)
Journal identifiersISSN: 0028-0836 • E-ISSN: 1476-4687
PublisherSpringer Science and Business Media LLC (PUBLISHER)
DOI10.1038/35057062
PMID11237011
OpenAlexW2168909179
LanguageEN
Citations received184
References cited414

The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.

Biology · Computational biology · Data science · DNA sequencing · Evolutionary biology · Gene · Genome · Human genome · Sequence (biology) · Whole genome sequencing · Computer Science · Genetics · Genomics and Chromatin Dynamics · Genomics and Phylogenetic Studies · RNA and protein synthesis mechanisms

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